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Determination of phthalate in PVC food wrap by gas chromatography mass spectrometry

Nguyen Thi Ha Binh Dang Thu Hien Tran Cao Son
Published 05/14/2023

Article Details

How to Cite
Nguyen Thi Ha Binh, Dang Thu Hien, Tran Cao Son. "Determination of phthalate in PVC food wrap by gas chromatography mass spectrometry". Vietnam Journal of Food Control. vol. 6, no. 2 (en), pp. 116-125, 2023

Main Article Content


Toxic phthalates that can be released from food packaging into food are currently a matter of concern, affecting consumers’ health. However, in Vietnam, no studies have been published on this group of substances in food packaging and films. In this research, a method for the simultaneous determination of 7 typical phthalates, including benzyl butyl phthalate (BBP), dibutyl phthalate (DBP), di(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), diisodecyl phthalate (DIDP), diisononyl phthalate (DINP), di-(2-ethylhexyl) adipate (DEHA) in food wrap samples by gas chromatography mass spectrometry (GC-MS) using internal standards has been developed and validated. The limit of detection and limit of quantification for all substances was 0.03 mg/kg and 0.10 mg/kg, respectively. The recoveries of the method were in the range of 82-105%. Relative standard deviation (RSD) ranged from 5.6 to 7.5%. The method has been applied effectively to analyze the content of phthalates in 35 food wrap samples that were collected from markets in Hanoi. Analytical results showed that ten samples were detected with phthalates, of which three samples contained DEHA exceeding the specific migration limit (SML). This study contributes to consumer health protection and advises the regulatory agency on the addition of safety regulations for PVC food wrap in particular and other food packaging materials in general.


GC-MS, internal standard, phthalate, DBP, BBP, DEHP, DEHA, DNOP, DIDP, DINP.


[1]. M. T. De a. Freire, “Plasticizers in Brazilian food-packaging materials acquired on the retail market,” Food Additives and Contaminants, vol. 23, no. 1, pp. 93-99, 2006.
[2]. Standards and Specifications for Utensils, Containers and Packages, Part I, II, Ministry of Food and Drug Safety, 2009.
[3]. Commission Regulation (Eu) No 10/2011 Commission Regulation (EU) No 10/2011, Official Journal of the European Union, 2011.
[4]. X. L. Cao, W. Zhao, and R. Churchill, “Occurrence of di-(2-ethylhexyl) adipate and phthalate plasticizers in samples of meat, fish, and cheese and their packaging films,” Journal of Food Protection, vol. 77, vo. 4, pp. 610-620, 2014.
[5]. Y. Tsumura, S. Ishimitsu, A. Kaihara, K. Yoshii II, Y. Nakamura, and Y. Tonogai, “Di(2-ethylhexyl) phthalate contamination of retail packed lunches caused by PVC gloves used in the preparation of foods,” Food Additives and Contaminants, vol. 18, no.6, pp. 569-579, 2010.
[6]. T. M. Tri, L. M. Thuy, N. T. N. Anh, L. T. Trinh, L. Q. Huong, P. T. P. Thao, and N. Q. Trung, “Determination method and distribution of phthalate diesters in beverage collected from Hanoi, Vietnam,” VNU Journal of Science: Natural Sciences and Technology, vol. 34, no. 4, pp. 16-20, 2018.
[7]. Circulars 14/2011/TT-BYT, “General guidance on food sampling for inspection, quality control, food hygiene and safety,” 2011.
[8]. AOAC Appendix F, “Methods Committee Guidelines for Standard Method Performance Requirement,” AOAC INTERNATIONAL, 2006.
[9]. T. C. Son, Method Validation and Uncertainty Assessment in Analytical Chemistry, Science and Technics Publishing House, 2021.