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Determination of some Aristolochic acid and Aristolactam in herbal dietary supplements containing Aristolochiaceae plants

Nguyen Thi Minh Hoa Dang Thi Hien Nguyen Thi Hong Ngoc Tran Cao Son Kim Thi Thanh Hien Pham Thi Thanh Ha
Received: 15 Feb 2022
Revised: 15 Mar 2022
Accepted: 15 Mar 2022
Published: 30 Jun 2022

Article Details

How to Cite
Nguyen Thi Minh Hoa, Dang Thi Hien, Nguyen Thi Hong Ngoc, Tran Cao Son, Kim Thi Thanh Hien, Pham Thi Thanh Ha. "Determination of some Aristolochic acid and Aristolactam in herbal dietary supplements containing Aristolochiaceae plants". Vietnam Journal of Food Control. vol. 5, no. 2 (en), pp. 115-128, 2022
PP
115-128
Counter
667

Main Article Content

Abstract

LC-MS/MS method providing high sensitivity for determination of five aristolochic acids (AA) and four aristolactams (AL) was built. Samples were extracted efficiently in Methanol: DMSO solvent. The detection limit of AA A, AL BII is 0.030 ng/g, of AL FI, AL AII is 0.15 ng/g, and of AA B, AA C, AA D, 7-OH AA A, AL I is 3.0 ng/g. Recoveries of nine target compounds were from 80.2 to 110%, and relative standard deviations were below 10.5%. The method was applied to simultaneously determine the content of nine target analytes in capsule, tablet, traditional round pill, and liquid herbal supplements collected from different drug stores in Hanoi, Vietnam. Results show that AA A, 7-OH AAA, and AL I compounds exist in 24 out of 30 health supplements. Among them, it is worth noting that three tablet samples without declaring ingredients belonged to Aristolochiaceae plants on the pack, but still be positive with AA A and AL I.

Keywords:

Aristolochiaceae, aristolochic acid, aristolactam, dietary supplement, LC-MS/MS.

References

[1]. C. Y. Zhang, X. Wang, T. Su, C. M. Ma, Y. J. Wen, M. Y. Shang, X. M. Li, G. X. Liu, and S Q Cai, "New aristolochic acid, aristololactam and renal cytotoxic constituents from the stem and leaves of Aristolochia contorta," Die Pharmazie, vol. 60, no. 10, pp. 785-788, 2005.
[2]. A. W. T. Ng, S. L. Poon, M. N. Huang, et al, "Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia," Science Translational Medicine, vol. 9, no. 412, 2017.
[3]. J. Michl, G. C. Kite, S. Wanke, O. Zierau, G. Vollmer, C. Neinhuis, M. S. J. Simmonds, and M.Heinrich, "LC-MS- and (1)H NMR-Based Metabolomic Analysis and in Vitro Toxicological Assessment of 43 Aristolochia Species," Journal of Natural Products, vol. 79, no. 1, pp. 30-37, 2016.
[4]. J. Michl, M. J. Ingrouille, M. S. J.Simmonds. and M. Heinrich, "Naturally occurring aristolochic acid analogues and their toxicities," Natural Product Report, vol. 31, no. 5, pp. 676–693, 2014.
[5]. A. M. Bode and Z. Dong, "Toxic phytochemicals and their potential risks for human cancer," Cancer Prevention Research (Philadenphia. Pa), vol. 8, no. 1, pp. 1-8, 2015.
[6]. A. P. Grollman and B. Jelaković, "Role of environmental toxins in endemic (Balkan) nephropathy," Journal of the American Society of Nephrology: JASN, vol. 18, no. 11, pp. 2817-2823, 2007.
[7]. S-H. Hsieh, M-H. Huang, B-S. Lin, and H-T. Chang, "Determination of aristolochic acid in Chinese herbal medicine by capillary electrophoresis with laser-induced fluorescence detection," Journal of Chromatography A, vol. 1105 (1-2), pp.127-134, 2006.
[8]. E. S. Ong and S. O. Woo, "Determination of aristolochic acids in medicinal plants (Chinese) prepared medicine using capillary zone electrophoresis," Electrophoresis, vol. 22, no. 11, pp. 2236-2241, 2001.
[9]. M. Araya, S. García, and M. González-Teuber, "Rapid identification and simultaneous quantification of aristolochic acids by HPLC-DAD and confirmations by MS in Aristolochia chilensis using a limited biomass," Journal of Analytical Methods Chemistry, vol. 2018, Article ID 5036542, 2018.
[10]. TCVN 11940:2017, Food supplements and vegetable ingredients - Determination of aristolochic acid-1 - Liquid chromatographic method with UV detector (LC-UV) and confirmation by mass spectrometry liquid chromatography. , [accessed: 02/ 11/2022].
[11]. S-A. Chan, M-J. Chen, T-Y. Liu, M-R. Fuh, J-F. Deng, M-L. Wu, and S-J. Hsieh, "Determination of aristolochic acids in medicinal plant and herbal product by liquid chromatography-electrospray-ion trap mass spectrometry," Talanta, vol. 60, no. 4, pp. 679-685, 2003.
[12]. J. Liu, Y. Liu, Y. Wu, Z. Dai, and S. Ma, "Rapid Analysis of Aristolochic Acid Analogues in Traditional Chinese Patent Medicine by LC-MS/MS," Journal of Analytical Methods Chemistry, vol. 2020, Article ID 8823596, 2020.
[13]. C.-Y. Huang, M.-C. Tseng, and J.-H Lin, "Analyzing aristolochic acids in Chinese herbal preparations using LC/MS/MS," Journal of Food and Drug Analysis, vol. 13, no. 2, pp. 125-131, 2005.
[14]. Union P.O. of the E. (2002). CELEX1, 2002/657/EC: Commission Decision of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results (Text with EEA relevance) (notified under document number C(2002) 3044). , [accessed: 02/11/2022].
[15]. Aristolochia-summary-report-committee-veterinary-medicinal-products_en.pdf. , [accessed: 03/15/2022].
[16]. Integrative Medicine: FDA Warning Regarding Aristolochic Acid | Memorial Sloan Kettering Cancer Center. , accessed: 02/11/2022.
[17]. L. Vaclavik, A. J. Krynitsky, and J. I. Rader, "Quantification of aristolochic acids I and II in herbal dietary supplements by ultra-high-performance liquid chromatography-multistage fragmentation mass spectrometry," Food Additive & Contaminant,s Part A, Chemistry Analysis Control, Exposure & Risk Assessment, vol. 31, no. 5, pp. 784-791, 2014.
[18]. M. J. Martena, J. C. A. van der Wielen, L. F. J van de Laak, E. J. M. Konings, H. N de Groot, I. M. C. M. Rietjens, "Enforcement of the ban on aristolochic acids in Chinese traditional herbal preparations on the Dutch market," Analytical and Bioanalytical Chemistry, vol. 389, no. 1, pp. 263-275, 2007.

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