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Simultaneous determination of benzyldimethyloctylammonium chloride and benzyldimethyldodecylammonium chloride by CE-C4D

Tran Thi My Hao Dinh Viet Chien Vo Thi Minh Anh Hoang Quoc Anh Kieu Van Anh Pham Thi Quynh Dinh Son Luong Pham Hoang Nguyen Tran Hoang Minh Anh Cao Cong Khanh Nguyen Van Khoa Le Thi Hong Hao Nguyen Thi Anh Huong
Received: 27 Apr 2023
Revised: 28 May 2023
Accepted: 28 May 2023
Published: 29 Sep 2023

Article Details

How to Cite
Tran Thi My Hao, Dinh Viet Chien, Vo Thi Minh Anh, Hoang Quoc Anh, Kieu Van Anh, Pham Thi Quynh, Dinh Son Luong, Pham Hoang Nguyen, Tran Hoang Minh Anh, Cao Cong Khanh, Nguyen Van Khoa, Le Thi Hong Hao, Nguyen Thi Anh Huong. "Simultaneous determination of benzyldimethyloctylammonium chloride and benzyldimethyldodecylammonium chloride by CE-C4D". Vietnam Journal of Food Control. vol. 6, no. 3, pp. 246-258, 2023
PP
246-258
Counter
283

Main Article Content

Abstract

Benzyldimethyloctylammonium chloride (BAC-C8) and Benzyldimethyldodecyl ammonium chloride (BAC-C12) are bactericidal surfactants which widely used in the pharmaceutical industry as anti-microbial disinfectants in skin antiseptic solution. According to current international regulations, the standard of finished antiseptic solution must have regulations on the limit of preservatives when used in the formulation. In this study, simultaneous determination of BAC-C8 and BAC-C12 was performed by capillary electrophoresis using capacitively coupled contactless conductivity detection (CE-C4D) with analytical conditions including: fused silica capillary (50 µm ID.) with effective length of 40 cm, background electrolyte solution of 100 mM acetic acid (Ace) added 30% acetonitril (ACN); hydrodynamic sample injection at height of 10 cm in 20 s; separation voltage of +15 kV. The detection limit of BAC-C8 and BAC-C12 were 1.5 mg/L and 3.5 mg/L, respectively. This method has been applied to determine the content of BAC-C8 and BACC12 in the disinfectant solution samples.

Keywords:

BAC-C8, BAC-C12, disinfectant, CE-C4D

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