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Determination of chlorate and perchlorate in pangasius samples by liquid chromatography tandem mass spectrometry (LC-MS/MS)

Huynh Thi Ngoc Lien Co Hong Son Nguyen Van Luy
Published 09/26/2022

Article Details

How to Cite
Huynh Thi Ngoc Lien, Co Hong Son, Nguyen Van Luy. "Determination of chlorate and perchlorate in pangasius samples by liquid chromatography tandem mass spectrometry (LC-MS/MS)". Vietnam Journal of Food Control. vol. 5, no. 3, pp. 474-487, 2022
PP
474-487
Counter
390

Main Article Content

Abstract

The LC-ESI-MS/MS method has been successfully developed for determination of chlorate and perchlorate in pangasius samples. Residues of chlorate and perchlorate in the sample were extracted with a methanolic solution acidified with 1% formic acid. Then, the extract was cleaned with C18 powder, used a normal phase column to separate chlorate and perchlorate, and quantified on an LC-ESI-MS/MS instrument. The method was validated for good specificity, linear calibration curve in the range of 0.0005 - 0.015 mg/L; the limit of quantification (LOQ) was 0.005 mg/kg; the recovery and relative standard deviation was from 91 to 109% and from 6.4 to 9.5% respectively and all met the requirements of SANTE. The method was applied to the real analysis, a total of 427 pangasius fillet samples collected from seafood processing companies. There were 76 samples were detected chlorate equivalent to 18%. The concentration of chlorate ranged from 0.43 to 253 mg/kg.

Keywords:

Chlorate and Perchlorate, LC-MS/MS, pangasius.

References

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