Bìa tạp chí



Research and application of direct mercury analyzer (DMA-80) quickly determination of total mercury contents in dietary supplements

Nguyen Thi Van Anh Nguyen Thi Trang Dinh Viet Chien Tran Hoang Giang Lu Thi Minh Hien Nguyen Minh Chau
Published 09/27/2022

Article Details

How to Cite
Nguyen Thi Van Anh, Nguyen Thi Trang, Dinh Viet Chien, Tran Hoang Giang, Lu Thi Minh Hien, Nguyen Minh Chau. "Research and application of direct mercury analyzer (DMA-80) quickly determination of total mercury contents in dietary supplements". Vietnam Journal of Food Control. vol. 5, no. 3, pp. 433-442, 2022

Main Article Content


The Direct Mercury Analyzer (DMA-80) was studied and investigated to quickly and accurately determine the total mercury content in health supplements. The method shows high specificity, and the calibration curve has a good correlation coefficient with R2 greater than 0.995; the limit of detection (LOD) and limit of quantification (LOQ) were 1.88 µg/kg and 6.26 µg/kg, respectively; The relative repeatability standard deviation (RSRr) was in the range of 2.46 - 7.34% and the recovery (R) was in the range of 85.7 - 100%. The method was applied to evaluate the mercury content in 39 health supplement samples taken in Hanoi city. The initial research results indicated preliminary mercury contamination in 13 health supplement products on the market in the range of 5.41 - 450 µg/kg.


mercury, DMA-80, health supplements.


[1]. R. A. Bernhoft, “Mercury toxicity and treatment: a review of the literature,” Journal of Environmental and Public Health, vol. 2012, 2012.
[2]. M. Sakamoto, M. Nakamura, and K. Murata, “Mercury as a Global Pollutant and Mercury Exposure Assessment and Health Effects,” Nihon Eiseigaku Zasshi, vol. 73, no. 3, pp. 258-264, 2018.
[3]. B. F. Azevedo, L. B. Furieri, and F. M. Peçanha, “Toxic Effects of Mercury on the Cardiovascular and Central Nervous Systems,” Journal of Biomedicine and Biotechnology, 949048, 2012.
[4]. João Guilherme Costa, Bojana Vidovic, Nuno Saraiva, “Contaminants: a dark side of food supplements,” Free Radical Ressearch, vol. 53 (sup1), pp. 1113-1135, 2019.
[5]. Claudia Carvalhinho Windmoller, Nayara Carolinne Silva, Pedro Henrique Morais Andrade, “Use of a direct mercury analyzer for mercury speciation in different matrices without sample preparation,” Analytical Methods, no. 14, 2017.
[6]. United States Environmental Protection Agency, “Method 7473 - Mercury in Solids and Solutions by Thermal Decomposition, Amalgamation, and Atomic Absorption Spectrophotometry,” 2007.
[7]. Ministry of Health, “National technical regulation on the limits of heavy metals contamination in food,” Hanoi, 2011.
[8]. ASEAN, “Annex III, Asean Guidelines on Limits of Contanminants for Health Supplements”. [Online]. Available: https://asean.org/wp-content/uploads/2017/09/
ASEAN Guidelines on Limts of contaminants-HS-V2.0-with-disclaimer.pdf [Accessed: 9/25/2022].
[9]. AOAC, “Appendix F: Guidelines for standard method performance requirements,” AOAC Official Methods of Analysis, 9, 2012.