Bìa tạp chí



Determination of adenosine and cordycepin in dietary supplements circulating on the Hanoi market

Nguyen Thanh Dat Nguyen Thi Hong Hanh Dam Thi Thu Nguyen Van Hieu Lai Thi Phuong Duong The Bac
Received: 25 Jul 2022
Revised: 19 Sep 2022
Accepted: 19 Sep 2022
Published: 05 Oct 2022

Article Details

How to Cite
Nguyen Thanh Dat, Nguyen Thi Hong Hanh, Dam Thi Thu, Nguyen Van Hieu, Lai Thi Phuong, Duong The Bac. "Determination of adenosine and cordycepin in dietary supplements circulating on the Hanoi market". Vietnam Journal of Food Control. vol. 5, no. 3, pp. 390-401, 2022

Main Article Content


High performance liquid chromatography with diode-array detector (HPLC-DAD) has been fully validated according to AOAC requirements for the determination of adenosine and cordycepin in dietary supplements containing Cordyceps. Chromatographic conditions using InertSustain C18 (250 mm × 4.6 mm; 5 µm) column, with gradient program composed of methanol and water eluted in 35 min, diode-array detector at 260 nm, flow rate of 1.0 mL/min. The study has determined the content of adenosine and cordycepin in 24 dietary supplement samples containing Cordyceps in different dosage forms circulating on the Hanoi market. The results showed that the contents of the two substances studied in the samples fluctuated greatly (adenosine from 28.19 - 956.3 µg/g with solid and oily form, from 1.26 - 25.31 µg/mL with the liquid form; cordycepin from 5.25 - 1287 µg/g with solid and oily form, from 1.91 - 32.38 µg/mL with liquid form), especially one sample was detected without both adenosine and cordycepin, one sample did not have adenosine.


Adenosine, Cordycepin, Cordyceps, dietary supplements, HPLC.


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