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Determination of sibutramine and phenolphthalein in weight­loss tea, coffee, and milk by ultra-­performance liquid chromatography mass spectrometry UPLC­-MS/MS

Truong Van Than Nguyen Thanh Duy Ly Tuan Kiet Hoang Ngoc Vinh Chu Van Hai
Published 09/12/2019

Article Details

How to Cite
Truong Van Than, Nguyen Thanh Duy, Ly Tuan Kiet, Hoang Ngoc Vinh, Chu Van Hai. "Determination of sibutramine and phenolphthalein in weight­loss tea, coffee, and milk by ultra-­performance liquid chromatography mass spectrometry UPLC­-MS/MS". Vietnam Journal of Food Control. vol. 2, no. 4, pp. 42-48, 2019
PP
42-48
Counter
547

Main Article Content

Abstract

A rapid, simply and effective method using ultra­performance liquid chromatography coupled to mass spectrometry (MS) detection was developed in order to determine sibutramine and phenolphthalein in weight­loss tea, coffee, and milk. QuEChERS technique was used for cleaning­up sample matrices. The extracts were separated on C18 LC columns using the gradient elution of 0.1% formic acid in distilled water and acetonitrile. The recoveries at the concentration of 50 µg/kg were from 90.1 to 105.8% (with RSDR of 4.04 ­ 4.24%), from 91.9 to 100.2% (with RSDR of 3.20 ­ 4.71%), and from 86.5 to 100.5% (with RSDR of 5.17 ­ 5.49%) for weight­loss tea, coffee, and milk, respectively. Method quantitation limits were of 30 µg/kg.

Keywords:

Sibutramine, phenolphthalein, dietary supplements, ultra­performance liquid chromatography mass spectrometry UPLC­MS/MS

References

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