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Application of ultra performance liquid chromatography- triple quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) for the determination of antibiotic residues in meat and fish

Nguyen Van Chinh Dang Mai Tuyet Trang Doan Thi Truc Kha Cao Thi Quynh Mai Le Van Thien Bui Huy Hoang Lam Van Tu
Published 09/05/2019

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How to Cite
Nguyen Van Chinh, Dang Mai Tuyet Trang, Doan Thi Truc Kha, Cao Thi Quynh Mai, Le Van Thien, Bui Huy Hoang, Lam Van Tu. "Application of ultra performance liquid chromatography- triple quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) for the determination of antibiotic residues in meat and fish". Vietnam Journal of Food Control. vol. 2, no. 3, pp. 24-30, 2019

Main Article Content


The residue of antibiotics in meat and meat products is one of the social problems for its effects and risks to human health, especially in the antibiotic resistance crisis. Nowadays, there are hundreds of drugs commercially available, with difference biochemical characteristics. Therefore, it is necessary to determine and monitor these residues in meat and meat products. The methods using liquid chromatography (LC) and ELISA are widely applied in numbers of laboratories to determine specified substances. In several laboratories, the state-of-the-art highresolution analytical technique, using Ultra Performance Liquid chromatography-triple quadrupole Time-of-flight mass spectrometry (UPLC-QTOF-MS), is applied to analyse the knowns and unknowns residues in food. In this study, we used this technique for screening the residue of antibiotics, banned substances (Sulfonamids, Quinolones, Tetracyclines, β-Agonists…) and other toxins in pork, chicken, beef and fish samples. Ninety-three randomly collected samples have been screened and residues of Amoxicillin, Cefalexin and Ampicillin have been detected in three of them.


Residues, antibiotics, meat, fish, QTOF


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