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Determination of crinamidine in dietary supplements by GC-MS/MS

Le Thi Lien Bach Thuy Anh Cao Cong Khanh Tran Nguyen Ha Le Thi Hong Hao
Received: 22 Jan 2018
Revised: 02 Mar 2018
Accepted: 09 Mar 2018
Published: 30 Mar 2018

Article Details

How to Cite
Le Thi Lien, Bach Thuy Anh, Cao Cong Khanh, Tran Nguyen Ha, Le Thi Hong Hao. "Determination of crinamidine in dietary supplements by GC-MS/MS". Vietnam Journal of Food Control. vol. 1, no. 1, pp. 3-7, 2018
PP
3-7
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687

Main Article Content

Abstract

The determination of crinamidine in dietary supplements content by mass spectrometry (GC-MS/MS) was developed and validated. The method was performed on the DB5MS column (30m x 0,25mm; 0,25 μm), in combination with the tandem mass spectrometry. The parameters of the method were evaluated for selectivity, calibration curve, accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ). The calibration curve was highly linear (the coefficient of determination 0.9970) within the concentration range of 5ppm-50ppm. The recovery at three concentrations were above 90,1%. The limit of detection (LOD) and limit of quantification (LOQ) of the methods were 3 and 10 mg/kg, respectively. All obtained results were acceptable according to the AOAC for dietary supplements. The method was applied to analyze 34 samples in Hanoi.

Keywords:

Crinamidine, Gas chromatography tandem mass spectrometry (GS-MS/MS)

References

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