Bìa tạp chí

Website: https://vjfc.nifc.gov.vn/

009bet

Development of reference materials for the determination of calcium, iron, selenium, and zinc in dietary supplements

Tran Thanh Son Dang Van Ket Dang Huu Cuong Tran Thi Thu Trang Nguyen Thi Thao Nguyen Dang Thi Oanh
Received: 09 Aug 2024
Revised: 21 Jun 2025
Accepted: 22 Jun 2025
Published: 30 Jun 2025

Article Details

How to Cite
Tran Thanh Son, Dang Van Ket, Dang Huu Cuong, Tran Thi Thu Trang, Nguyen Thi Thao Nguyen, Dang Thi Oanh. "Development of reference materials for the determination of calcium, iron, selenium, and zinc in dietary supplements". Vietnam Journal of Food Control. vol. 8, no. 2, pp. 106-114, 2025
PP
106-114
Counter
5

Main Article Content

Abstract

Food supplements are increasingly popular among consumers because of their convenience and nutritional value. Among the ingredients, essential minerals are added a lot because of their effects on health at all ages especially calcium (Ca), iron (Fe), selenium (Se), and zinc (Zn). To ensure the quality of products meets the requirements of consumers, the strengthening of control methods through testing is necessary. To ensure the quality of testing results, reference material/certified reference material is an effective tool for each laboratory. Nowadays, the source of reference material/certified reference material is highly dependent on overseas suppliers with expensive costs and inconvenient supply. This research was carried out in order to successfully produce a certified reference material of Ca, Zn, Fe and Se dietary supplements that can be supplied to domestic laboratories. Research results have produced certified reference material with characteristic values for Ca, Zn, Fe and Se content as follows: 786 ± 19.8 (mg/100g); 6.35 ± 0.40 (mg/100g); 7.42 ± 0.30 (mg/100g); and 18.4 ± 1.10 (µg/100g), respectively. The estimation of product shelf life is up to 1197 days.

Keywords:

reference material, certified reference material, dietary supplements, minerals.

References

[1]. S. Caroli et al., “A pilot study for the production of a certified reference material for trace elements in honey,” Microchemical Journal, vol. 67, no. 1–3, pp. 227–233, 2000.
[2]. H. Nguyen Thi, P. T. Le Thi, H. C. Dang, H. T. Luu Thi, and H. H. Le Thi, “Study on the production of Reference Material (RM) for Vitamin B1, B2, B6 in health supplements,” Vietnam Journal of Food Control, vol. 4, no. 4, pp. 307–314, 2021.
[3]. P. T. Le Thi, H. Nguyen Thi, H. Tran Thi, and C. Nguyen Minh, “Study on the Production of Reference Material of Heavy Metals (As, Cd, Pb, Hg) in Water,” Vietnam Journal of Food Control, vol. 5, no. 1, pp. 37–46, 2022.
[4]. P. T. Le Thi et al., “Production of certified reference material Escherichia coli in milk-based product,” Vietnam Journal of Food Control, vol. 5, no. 4, pp. 598–607, 2022.
[5]. K. E. Sharpless, S. Margolis, and J. Brown Thomas, “Determination of vitamins in food-matrix Standard Reference Materials,” Journal of Chromatography A, vol. 881, iss. 1–2, pp. 171–181, 2000.
[6]. J. B. Thomas, J. H. Yen, M. M. Schantz, B. J. Porter, and K. E. Sharpless, “Determination of caffeine, theobromine, and theophylline in standard reference material 2384, baking chocolate, using reversed-phase liquid chromatography,” Journal of Agricultural and Food Chemistry, vol. 52, no. 11, pp. 3259–3263, 2004.
[7]. M. M. Schantz et al., “Development of botanical and fish oil standard reference materials for fatty acids,” Analytical and Bioanalytical Chemistry, vol. 405, no. 13, pp. 4531–4538, 2013.
[8]. J. Lee et al., “Development of an infant formula certified reference material for the analysis of organic nutrients,” Food Chemistry, vol. 298, pp. 125088, 2019.
[9]. M. Rutkowska, J. Namieśnik, and P. Konieczka, “Production of certified reference materials - homogeneity and stability study based on the determination of total mercury and methylmercury,” Microchemical Journal, vol. 153, no. 2019, pp. 104338, 2020.
[10]. Ministry of Health, QCVN 8-2:2011/BYT – National Technical Regulation on the Limits of Heavy Metal Contaminants in Food, 2010 [in Vietnamese].
[11]. Ministry of Health, QCVN 8-1:2011/BYT – National Technical Regulation on the Limits of Mycotoxin Contaminants in Food, 2011 [in Vietnamese].
[12]. Ministry of Health, Circular No. 43/2014/TT-BYT on the Regulation of Functional Food Management, 2014 [in Vietnamese].
[13]. A. Catharine. Ross, “DRI, Dietary Reference Intakes : Calcium, Vitamin D”. National Academies Press, 2011.
[14]. H. Górska-Warsewicz, K. Rejman, W. Laskowski, and M. Czeczotko, “Milk and Dairy Products and Their Nutritional Contribution to the Average Polish Diet,” Nutrients, vol. 11, no. 8, pp. 1771, 2019.
[15]. AOAC Official Method, Calcium, Copper, Iron, Magnesium, Manganese, Potassium, Phosphorus, Sodium, and Zinc in Fortified Food Products. Microwave Digestion and Inductively Coupled Plasma-Optical Emission Spectromatry, 2011.
[16]. AOAC Official Method, Minerals and Trace Elements in Infant Formula. 2015.
[17]. International Standard Organization, “ISO 13528:2022 Statistical methods for use in proficiency testing by interlaboratory comparisons,” 2022.
[18]. “z -Scores and other scores in chemical proficiency testing—their meanings, and some common misconceptions,” Analytical Methods, vol. 8, no. 28, pp. 5553–5555, 2016.
[19]. International Standard Organization, ISO GUIDE 35:2017 Reference Materials - Guidance for characterization and assessment of homogeneity and stability, 2017.
[20]. National Institute of Standard and Technology, “SRM 1846 (Infant Formula) Certificate of Analysis,” no. 9, pp. 1–10, 2007.
[21]. National Institute of Standard and Technology, “SRM 3233 (Fortified Breakfast Cereal) Certificate of Analysis,” Sigma-Aldrich, no. 281, pp. 1, 2019.

 Submit