The inductively coupled plasma mass spectrometry (ICP-MS) method is applied to determine the content of heavy metals (Pb, Cd, As, Hg) in food and animal feed samples at the National Institute for Food Control due to its high accuracy and quick response time. These samples were digested in a microwave using a mixture of nitric acid and hydrogen peroxide, with the yttrium internal standard added initially to control the analysis. The efficiency of the method was evaluated to meet the requirements of AOAC with reasonable specificity, working standard curve for elements in the range from 0.4 to 20 µg/L, the relative standard deviation of repeatability RSDr < 3,55%, and the recoveries (R%) ranged from 92.2 to 103.1%. The method has been validated by participating in international proficiency testing programs in 2021 and 2022 with a value of |z-score| ≤ 2. Therefore, the results affirm the laboratory's competency meets the requirements for the validity of test results ISO/IEC 17025 requirements, reliability for customers and authorities.
Lead, Cadmium, Arsenic, Mercury, ICP-MS, method efficiency
[1]. B. P. Jackson & T. Punshon, “Recent advances in the measurement of arsenic, cadmium, and mercury in rice and other foods,” Current Environmental Health Reports, vol. 2, no. 1, pp. 15–24, 2015.
[2]. K. X. Yang & K. Swami, “Determination of metals in marine species by microwave digestion and inductively coupled plasma mass spectrometry analysis,” Spectrochimica Acta, Part B: Atomic Spectroscopy, 62, pp. 1177–1181, 2007.
[3]. J. Djeddjibegovic, T. Larssen, A. Skrbo, A. Marjanovic, M. Sober, “Contents of cadmium, copper, mercury and lead in fish from the Neretva river (Bosnia and Herzegovina) determined by inductively coupled plasma mass spectrometry (ICPMS),” Food Chemistry, Vol. 131, no. 2, pp 469-476, 2012.
[4]. E. P. Nardi, F. S. Evangelista, L. Tormen, T. D. Saint´Pierre, A. J. Curtius, S. S. de Souza, F. Barbosa Jr (2007). “ The use of inductively coupled plasma mass spectrometry (ICP-MS) for the determinatinon of toxic and essential elements in different types of food samples,” Simultaneous Determination of 25 Ergot Alkaloids in Cereal Samples by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry,” Food Chemistry, Vol. 112, no. 3, pp 727-732, 2009.
[5]. AOAC International, AOAC Official Method 2015.01, Determination of Heavy Metals in Food by Inductively Coupled Plasma-Mass Spectrometry First Action 2015.