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Study on the anti-arthritic effects of Tinospora sinensis Merr.

Nguyen Duc Thanh Vy Quoc Tuan Nguyen Dang Long Vu Nguyen Quang Dung Pham Van Toan Nguyen Cong Cuong Nguyen Thi Van Anh
Received: 10 May 2023
Revised: 26 May 2023
Accepted: 26 May 2023
Published: 30 Jun 2023

Article Details

How to Cite
Nguyen Duc Thanh, Vy Quoc Tuan, Nguyen Dang Long Vu, Nguyen Quang Dung, Pham Van Toan, Nguyen Cong Cuong, Nguyen Thi Van Anh. "Study on the anti-arthritic effects of Tinospora sinensis Merr.". Vietnam Journal of Food Control. vol. 6, no. 2 (en), pp. 199-209, 2023
PP
199-209
Counter
350

Main Article Content

Abstract

The Tinospora sinensis Merr. was ultrasonically extracted using 80% ethanol at a temperature of 50°C. The resulting solution was distilled to remove the solvent under reduced pressure, yielding the extract. The extract was then dissolved in distilled water, and this solution was administered to the experimental mice. The results showed that even at the maximum allowable dose, no mice experienced mortality. The anti-inflammatory effects of Tinospora sinensis Merr. extract were tested in experiments. The results demonstrated that at a dose equivalent to 1.6 g of plant material per kilogram of body weight per day, the extract exhibited acute anti-inflammatory activity in a model of carrageenan-induced foot edema in mice, comparable to a dose of 80 mg/kg body weight per day of aspirin. Additionally, at a dose equivalent to 2.8 g of plant material per kilogram of body weight per day, the extract showed chronic anti-inflammatory effects in a model of amian-induced granuloma in white mice. These findings suggest a novel direction in using plant-derived medicines, specifically the Tinospora sinensis Merr.

Keywords:

Tinospora sinensis Merr. extract, anti-arthritic, in vivo.

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