Phthalates consumed from milk: safety assessment for the population

Published 04/16/2021

Article Details

How to Cite
Sergey Evgen’evich Zelenkin, Tatyana Dmitrievna Karnazhitskaya. "Phthalates consumed from milk: safety assessment for the population". Vietnamese Journal of Food Control. vol. 4, no. 2 (en), pp. 85-98, 2021

Main Article Content


Phthalates, or phthalic acid ethers, are hazardous for human health as they produce negative effects on the endocrine system and liver when entering a body. Alimentary introduction into a body with food products is a priority for phthalates. Phthalates contents in milk are of particular interest since milk is the most popular food product among the population. It is vital to assess whether phthalates consumption from milk is safe for people due to their potential contents in this product and their potential hazards for human health. Research results indicate that when phthalates are introduced with milk it creates unacceptable non-carcinogenic risks for the examined children. Assessment of hazards caused by phthalates introduction allowed revealing that calculated phthalates doses were not safe as per adherence to the reference dose both for children and examined adults. The carcinogenic risk was also estimated as unacceptable both for children and adults.


phthalates, safety, polymer package, milk, migration.


[1]. Jasna Bosnir, Dinko Puntarić, Ivo Skes, Maja Klarić, Spomenka Simić, and Ivan Zorić, “Migration of Phthalates from Plastic Products to Model Solutions,” Collegium Antropologicum, vol. 27, suppl. 1, pp. 23-30, 2003.
[2]. P. Ventrice, D. Ventrice, E. Russo, and G. De Sarro, “Phthalates: European regulation, chemistry, pharmacokinetic and related toxicity,” Environmental Toxicology and Pharmacology, no. 36, pp. 88-96, 2013.
[3]. K. Tønning, E. Jacobsen, E. Pedersen, and N. H. Nillsson, “Phthalates in products that children are in direct contact with,” Survey of Chemical Substances in Consumer Products, no. 109, pp. 1-60, 2010.
[4]. L. Castle, A. Mayo, and J. Gilbert, “Migration of plasticizers from printing inks into foods,” Food Additives & Contaminants, vol. 6, no. 4, pp. 437-443, 1989.
[5]. Xu-Liang Cao, “Phthalate Esters in Foods: Sources, Occurrence, and Analytical Methods,” Comprehensive Reviews in Food Science and Food Safety, vol. 9, pp. 21-43, 2010.
[6]. Council Directive of 19 December 1985 “laying down the list of simulants to be used for testing migration of constituents of plastic materials and articles intended to come into contact with foodstuffs (85/572/EEC),” Official Journal of the European Communities, no L 372/14, 1985.
[7]. E. Fasano, F. Bono-Blay, T. Cirillo, P. Montuori, and S. Lacorte, “Migration of phthalates, alkylphenols, bisphenol A and di (2-ethylhexyl) adipate from food packaging,” Food Control, vol 27, pp. 132-138, 2012.
[8]. Commission Directive 2007/19/EC “amending Directive 2002/72/EC relating to plastic materials and articles intended to come into contact with food and Council Directive 85/572/EEC laying down the list of simulants to be used for testing migration of constituents of plastic materials and articles intended to come into contact with foodstuffs,” Official Journal of the European Commission, 2007.
[9]. Statistical Yearbook of Vietnam 2019 [Online]. Available: [Accessed 13/12/2020].
[10]. Diet of the population-2013. Statistical collection. Moscow, 2016 (in Russian).
[11]. M. Krejčíková, and A. Jarošová, “Phthalates in cow milk depending on the method of milking,” MENDELNET, pp. 592-596, 2013.
[12]. Technical Regulations of the Customs Union 005/2011 «On the safety of packaging» [Onlne]. Available: [Accessed 13/12/2020] (in Russian).
[13]. T. Karnazhitskaya, M. Antipyeva, and E. Zavernenkova, “Determination of phthalates in drinking milk by the method of high efficiency liquid chromatography,” Conference proceeding - All-Russian scientific and practical conference with international participation, Perm, 2014, pp. 531-535 (in Russian).
[14]. Quantitative assessment of non-carcinogenic risks caused by exposure to chemicals based on building up evolution models. Methodological guidelines MG [Online]. Available: [Accessed 13/12/2020] (in Russian).
[15]. M. Goumenou, and A. Tsatsakis, “Proposing new approaches for the risk characterisation of single chemicals and chemical mixtures: The source related hazard quotient (HQS) and hazard index (HIS) and the adversity specific hazard index (HIA),” Toxicology Reports, no. 6, pp. 632-636, 2019.
[16]. M. A. Kamrin, “Phthalate risks, phthalate regulation, and public health: a review,” Journal of Toxicology and Environmental Health, Part B: Critical Review, no. 12, pp. 157-174, 2009.
[17]. S. H. Swan, “Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans,” Environmental Research., no. 108, pp. 177-184, 2008.
[18]. V. Chopra, K. Harley, M. Lahiff, and B. Eskenazi, “Association between phthalates and attention deficit disorder and learning disability in U.S. children, 6-15 years,” Environmental Research, no. 128, pp. 64-69, 2014.
[19]. T. N. Lovekamp, and B. J. Davis, “Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat garnulosa cells,” Toxicology and Applied Pharmacology, no. 172, pp. 217-224, 2001.
[20]. M. D. Spillmann, M. Siegrist, C. Keller, and M. Wormuth, “Phthalate exposure through food and consumers’ risk perception of chemicals in food,” Risk Analysis, no. 29, pp. 1170-1180, 2009.
[21]. I. Svechnikova, K. Svechnikov, and O. Soder, “The influence of di-(2-ethylhexyl) phthalate on steroidogenesis by the ovarian granulose cells of immature female rats,” Journal of Endocrinology, no. 194, pp. 603-609, 2007.
[22]. E. K. Maloney, and D. J. Waxman, “Trans-activation of PPARαAnd PPARγ by structurally diverse environmental chemicals,” Toxicology and Applied Pharmacology, no. 161, pp. 209-218, 1999.
[23]. W. M. Kluwe, “Overview of phthalate ester pharmacokinetics in mammalian species,” Environmental Health Perspectives, no. 45, pp. 3-9, 1982.
[24]. P-C. Huang, P-L. Kuo, Y-L. Guo, P-C. Liao, and C-C. Lee, “Associations between urinary phthalate monoesters and thyroid hormones in pregnant women,” Human Reproduction, vol. 22, pp. 2715-2722, 2007.
[25]. J. D. Meeker, and K. K. Ferguson, “Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008,” Environmental Health Perspectives, vol. 119, pp. 1396-1402, 2011.
[26]. J. D. Meeker, A. M. Calafat, and R. Hauser, “Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men,” Environmental Health Perspectives, vol. 115, pp. 1029-1034, 2007.
[27]. M. Boas, H. Frederiksen, U. Feldt-Rasmussen, N. E. Skakkebæk, L. Hegedüs, L. Hilsted, A. Juul, and K. M. Main, “Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth,” Environmental Health Perspectives, vol. 118, pp. 1458-1464, 2010.
[28]. Diethyl phthalate; CASRN 84-66-2. Integrated Risk Information System (IRIS) [Online]. Available: [Accessed 13/12/2020].
[29]. Di(2-ethylhexyl) phthalate (DEHP); CASRN 117-81-7. Integrated Risk Information System (IRIS) [Online]. Available: [Accessed 13/12/2020].
[30]. Dibutyl phthalate (DBP). Integrated Risk Information System (IRIS) [Online]. Available: [Accessed 13/12/2020].
[31]. Dimethyl phthalate. Integrated Risk Information System (IRIS) [Online]. Available: [Accessed 13/12/2020].
[32]. Butyl benzyl phthalate (BBP). Integrated Risk Information System (IRIS) [Online]. Available: [Accessed 13/12/2020].
[33]. Agents Classified by the IARC Monographs, Volumes 1-128 [Online]. Available: [Accessed 13/12/2020].
[34]. European Food Safety Authority, “Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to butylbenzylphthalate (BBP) for use in food contact materials,” EFSA Journal, no. 241, pp. 1-14, 2005.