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Determination of sibutramine and phenolphthalein in weight­loss tea, coffee, and milk by ultra-­performance liquid chromatography mass spectrometry UPLC­-MS/MS

Truong Van Than Nguyen Thanh Duy Ly Tuan Kiet Hoang Ngoc Vinh Chu Van Hai
Published 09/12/2019

Article Details

How to Cite
Truong Van Than, Nguyen Thanh Duy, Ly Tuan Kiet, Hoang Ngoc Vinh, Chu Van Hai. "Determination of sibutramine and phenolphthalein in weight­loss tea, coffee, and milk by ultra-­performance liquid chromatography mass spectrometry UPLC­-MS/MS". Vietnam Journal of Food Control. vol. 2, no. 4, pp. 42-48, 2019
PP
42-48
Counter
531

Main Article Content

Abstract

A rapid, simply and effective method using ultra­performance liquid chromatography coupled to mass spectrometry (MS) detection was developed in order to determine sibutramine and phenolphthalein in weight­loss tea, coffee, and milk. QuEChERS technique was used for cleaning­up sample matrices. The extracts were separated on C18 LC columns using the gradient elution of 0.1% formic acid in distilled water and acetonitrile. The recoveries at the concentration of 50 µg/kg were from 90.1 to 105.8% (with RSDR of 4.04 ­ 4.24%), from 91.9 to 100.2% (with RSDR of 3.20 ­ 4.71%), and from 86.5 to 100.5% (with RSDR of 5.17 ­ 5.49%) for weight­loss tea, coffee, and milk, respectively. Method quantitation limits were of 30 µg/kg.

Keywords:

Sibutramine, phenolphthalein, dietary supplements, ultra­performance liquid chromatography mass spectrometry UPLC­MS/MS

References

1. Nguyen Hong Vu, 2 chất cấm có trong trà giảm cân Golean Detox nguy hiểm thế nào, Báo sức khỏe đời sống, (2019).
2. Wang, D., Man, R., Shu, M., Liu, H., Gao, Y., & Luan, F. (2016), “Detection of sibutramine and phenolphthalein in functional foods using capillary electrophoresis”, Analytical Meth ods, 8 (3), 621 ­ 626.
3. Kim, J. Y., Park, H. J., Kim, J. W., Lee, J. H., Heo, S., Yoon, C. Y., & Cho, S. (2016), “Development and validation of UPLC and LC­MS/MS methods for the simultaneous determination of anti­obesity drugs in foods and dietary supplements”, Archives of pharmacal research, 39 (1), 103 ­ 114.
4. Paíga, P., Rodrigues, M. J., Correia, M., Amaral, J. S., Oliveira, M. B. P., & Delerue­Matos, C. (2017), “Analysis of pharmaceutical adulterants in plant food supplements by UHPLCMS/MS”, European Journal of Pharmaceutical Sciences, 99, 219 ­ 227.
5. Petkova­Gueorguieva, E., Ivanov, K., Gueorguiev, S., Mihaylova, A., Madzharov, V., & Ivanova, S. (2018), “Detection of sibutramine in herbal food supplements by UHPLC/HRMS and UHPLC/MS­MS”, Biomedical Research, 29 (14), 3006 ­ 3009.
6. Guidelines for Standard Method Performance Requirements, AOAC Official Methods of Analysis (2016).
7. Guidance document on analytical quality control and validation procedures for pesticide residues analysis in food and feed, SANCO/12571/2013.

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